Design, synthesis and biological evaluation of novel beta-substituted indol-3-yl ethylamido melatoninergic analogues
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K Iakovou1, A Varvaresou, A P Kourounakis
1School of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimiopolis-Zografou, Greece.
The Journal of Pharmacy and Pharmacology
|February 7, 2002
Abstract:
A series of new melatonin analogues have been synthesized. Interestingly, two of the new compounds, 11c and 11e, which did not show any appreciable affinity for the melatonin receptor, were found to be potent inhibitors of lipid peroxidation in rat liver microsomes. Analogue 11c, in particular, is a better antioxidant than melatonin.
