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[The percentage of free prostate specific antigen used in detecting prostate cancer]
1Department of Urology, Huashan Hospital, Shanghai Medical University, Shanghai 200040.
Objective:
To evaluate the value of the percentage of free prostate specific antigen in detecting prostate cancer.
Methods:
Serum free prostate specific antigen (F-PSA) and total PSA were measured with immunoradiometric assay, and the free/total PSA ratio was calculated. In 117 patients, 31 had prostate carcinoma and 86 BPH.
Results:
The free/total PSA ratio was lower in patients with prostate cancer than in those with BPH. If the total serum PSA level was limited with in 4 - 10 ng/ml, the free/total PSA ratio can be used in the differential diagnosis of prostate cancer and BPH except total PSA.
Conclusions:
The free/total PSA ratio can be used in the differential diagnosis of prostate cancer and BPH, especially when serum PSA level is limited with in 4 - 10 ng/ml.
