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[Plasma thyroid hormones during cardiopulmonary bypass]
1Department of Cardiothoracic Surgery, Nanjing Genaral Hospital, People's Liberation Army, Nanjing 210002.
Objective:
To study the changes and clinical significance of plasma thyroid hormones were during cardiopulmonary bypass (CPB).
Methods:
Plasma thyroid hormones was studied in 36 patients during open heart surgery under CPB. Blood samples were taken preoperatively, and 1, 2, 3, 4, 5 days postoperatively. Doppler echocardiography was performed in 16 patients before and after surgery for evaluating heart function.
Results:
Before CPB, the levels of thyroid hormones were within normal range. At early stage after CPB, the levels of FT(3), FT(4), TT(3) and TT(4) were significantly decreased and increased. Both TSH and rT(3) were increased significantly after CPB (P < 0.05) and reached their highest levels at the first postoperative day. TSH and rT(3) were gradually dropped subsequently, but TSH returned to the basic level and the level of rT(3) was still high. A positive relation was seen between plasma thyroid hormones and cardiac function.
Conclusions:
The changes of plasma thyroid hormones are closely related to cardiopulmonary bypass and could result in postoperative cardiac disfunction.