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[Plasma thyroid hormones during cardiopulmonary bypass].
1Department of Cardiothoracic Surgery, Nanjing Genaral Hospital, People's Liberation Army, Nanjing 210002.
Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|February 7, 2002
Summary
Cardiopulmonary bypass (CPB) significantly alters plasma thyroid hormones, with TSH and rT(3) increasing post-surgery. These hormonal changes correlate with cardiac function, potentially leading to postoperative cardiac dysfunction.
Area of Science:
- Endocrinology
- Cardiovascular Surgery
- Physiology
Context:
- Cardiopulmonary bypass (CPB) is a critical procedure in open-heart surgery.
- Thyroid hormones play a vital role in regulating metabolism and cardiac function.
- Understanding perioperative hormonal shifts is crucial for patient outcomes.
Purpose:
- To investigate the dynamic changes in plasma thyroid hormones during and after CPB.
- To assess the clinical significance of these hormonal alterations on cardiac function.
Summary:
- Plasma thyroid hormone levels (FT3, FT4, TT3, TT4) were measured preoperatively and up to 5 days post-CPB in 36 patients.
- Thyroid-stimulating hormone (TSH) and reverse T3 (rT3) significantly increased post-CPB, peaking on postoperative day 1.
- A positive correlation was observed between plasma thyroid hormone levels and cardiac function, assessed by Doppler echocardiography.
Impact:
- CPB induces significant alterations in thyroid hormone profiles.
- Postoperative cardiac dysfunction may be linked to these thyroid hormone changes.
- Monitoring thyroid hormones could aid in managing patients undergoing CPB.