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[Expression and significance of MXR7 mRNA in human hepatocellular carcinoma]
1International Co-operation Laboratory for Biological Signal Transduction Research and Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438.
Objective:
To find out the expression and significance of MXR7 mRNA in human hepatocellular carcinoma.
Methods:
The (32)P labeled and purified PCR product of MXR7 cDNA was taken as probe. MXR7 mRNA expression was detected by Northern blot analysis in 30 samples of preoperatively untreated HCC and corresponding surrounding non-cancerous hepatic tissue, and 12 normal liver tissues confirmed pathologically.
Results:
The frequency of MXR7 mRNA expression in HCC, the corresponding surrounding noncancerous hepatic, and normal liver tissues was 76.6%, 13.3% and 0, respectively. The frequency of MXR7 mRNA expression in HCC without serum AFP elevation and in HCC < 5 cm was 9/10 and 5/6 respectively.
Conclusions:
MXR7 mRNA over-expression in human HCC is common and MXR7 mRNA may be expressed at early stage of HCC and can serve as tumor biomarker for HCC. The detection of MXR7 mRNA expression in liver puncture tissues may find small HCC without serum AFP elevation in the subclinical stage.
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