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[Lactulose mannitol ratio in patients after operation]
1Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730.
Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|February 7, 2002
Summary
The lactulose/mannitol (L/M) ratio in urine increases 5 days post-operation, indicating heightened intestinal permeability. This L/M ratio correlates with the severity of surgical stress.
Area of Science:
- Gastroenterology
- Surgical Stress Response
- Biomarker Discovery
Context:
- Post-operative recovery is influenced by physiological stress.
- Intestinal permeability is a sensitive indicator of systemic stress.
- Assessing gut barrier function aids in understanding patient outcomes.
Purpose:
- To evaluate the urinary lactulose/mannitol (L/M) ratio as a marker of intestinal permeability after surgery.
- To investigate the relationship between the L/M ratio and the severity of surgical stress, assessed by APACHE II scores.
Summary:
- The study measured the L/M ratio in 20 surgical patients pre-operatively and on days 5 and 10 post-operatively using HPLC.
- A significant increase in the L/M ratio was observed on postoperative day 5 (P < 0.01), returning to baseline by day 10.
- A strong correlation (r = 0.762) was found between the elevated L/M ratio and the severity of surgical stress.
Impact:
- The urinary L/M ratio serves as a valuable, non-invasive biomarker for assessing intestinal barrier dysfunction following surgery.
- Findings suggest that increased intestinal permeability post-operation is linked to the degree of physiological stress experienced by the patient.
- This research may inform clinical monitoring and management strategies for surgical patients.