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[Liver metastasis in colorectal cancer and tumor angiogenesis]
1Department of Surgery, Institute of Cancer Research, Beijing Medical University, Beijing 100036.
Objective:
To investigate the association between tumor angiogenetic activity and metastatic potential of colorectal cancer (CRC) retrospectively.
Methods:
The microvessel density (MVD) and the level of vascular endothelial growth factor (VEGF) expression were examined immunohistochemically from 61 specimens obtained by surgical resection of CRC.
Results:
MVD was (27.0 +/- 8.4) and the expression of VEGF was (59.75 +/- 12.36)%. Both were significantly higher in the group of liver metastasis, and in the group of lymph node metastasis (P < 0.01, P < 0.05). Survival analysis indicated a significant difference between increasing MVD group and the control group (P < 0.01).
Conclusions:
VEGF-mediated angiogenesis plays an important role in liver metastasis of CRC, and MVD appears to be a new prognostic factor for the prediction of outcome in patients with CRC.