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[E-CD expression and its clinical significance in human bladder carcinoma]
Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|February 7, 2002
Summary
Reduced E-cadherin (E-CD) expression indicates higher grade and stage in bladder cancer. Detecting E-CD levels may predict recurrence and prognosis in transitional cell carcinoma.
Area of Science:
- Oncology
- Biochemistry
Context:
- Bladder transitional cell carcinoma (TCC) is a significant health concern.
- Understanding molecular markers for TCC progression is crucial.
Purpose:
- To investigate the expression of E-cadherin (E-CD) protein.
- To determine the clinical significance of E-CD in human recurrent bladder TCC.
Summary:
- Immunohistochemistry assessed E-CD expression in 54 bladder TCC cases.
- Decreased E-CD correlated with higher tumor grade and stage.
- Abnormal E-CD expression linked to increased recurrence and poorer survival.
Impact:
- E-cadherin expression serves as a valuable marker for carcinoma malignancy.
- E-CD detection can aid in assessing bladder TCC malignancy, recurrence risk, and prognosis.