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[Changes of interleukin-2 and soluble interleukin-2 receptor serum level and multiple organ dysfunction syndrome in
Objective:
To evaluate the role in the changes of interleukin-2 (IL-2) and soluble interleukin-2R (sIL-2R) serum level in the mechanism of post-traumatic multiple organ dysfunction syndrome (MODS).
Methods:
59 severe traumatic patients were divided into MODS group (n = 24) and non-MODS group (n = 35) according to the occurrence of MODS after trauma. The changes in IL-2 and sIL-2R serum level were observed by enzyme linked immunoabsorbed assay (ELISA). Sera from 30 healthy individuals were used as normal controls.
Results:
The serum level of sIL-2R was increased and that of IL-2 decreased in 59 traumatic patients. These changes were more marked in the MODS group than in non-MODS group (p < 0.05).
Conclusions:
The changes in IL-2 and sIL-2R serum level after trauma might participate in the mechanism of post-traumatic MODS.
Insights
Serum levels of interleukin-2 (IL-2) and soluble interleukin-2 receptor (sIL-2R) change after severe trauma. These alterations, particularly decreased IL-2 and increased sIL-2R, are more pronounced in patients developing multiple organ dysfunction syndrome (MODS).
Area of Science:
- Immunology
- Critical Care Medicine
- Biochemistry
Context:
- Severe trauma can lead to multiple organ dysfunction syndrome (MODS).
- Interleukin-2 (IL-2) and its soluble receptor (sIL-2R) are key immune signaling molecules.
- Understanding immune marker dynamics is crucial for predicting MODS development.
Purpose:
- To investigate the association between serum IL-2 and sIL-2R levels and the development of post-traumatic MODS.
- To elucidate the potential role of IL-2 and sIL-2R in MODS pathogenesis.
Summary:
- Serum levels of sIL-2R were elevated, while IL-2 levels were decreased in 59 severe trauma patients.
- These changes were significantly more pronounced in patients who developed MODS compared to those who did not.
- Enzyme-linked immunosorbent assay (ELISA) was used to quantify IL-2 and sIL-2R levels.
Impact:
- The study suggests that altered IL-2 and sIL-2R serum levels may be involved in the mechanism of post-traumatic MODS.
- Findings could inform early diagnostic or prognostic markers for MODS.
- Further research may explore therapeutic interventions targeting the IL-2 pathway in trauma patients.