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Updated: Aug 3, 2026

The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System
11:27

The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System

Published on: April 25, 2012

SB-236057-A: a selective 5-HT1B receptor inverse agonist

C Roberts1, J Watson, G W Price

  • 1Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Ave., Harlow, Essex, CM19 5AW, UK. Claire_Roberts-1@gsk.com

CNS Drug Reviews
|February 7, 2002
PubMed
Summary

SB-236057-A is a potent 5-HT1B receptor inverse agonist that acts as an antagonist at terminal 5-HT autoreceptors. This compound increases extracellular serotonin in the dentate gyrus, suggesting potential for rapid antidepressant effects.

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