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Experimental evidence for a non-renin mediated pathway during TAME-esterase induced contractions in rat aorta in
1Department of Health and Medical Sciences, Faculty of Science, University of Mauritius, Reduit.
Indian Journal of Experimental Biology
|February 8, 2002
Abstract:
Possible pharmacological effects of N-alpha-tosyl L-arginine methyl ester [TAME] were studied on rat aorta strips in vitro. Results showed that [TAME]-esterase was an endothelium dependent component that involved a nitric oxide cyclic-GMP mediated pathway. Furthermore, during activation of Kinin-Kallikrein system, TAME-esterase induced contractions involve degradation of kinins by kininases.
