Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive impairments in multiple sclerosis: a review.

Eduardo Adonias DeSousa1, Ross H Albert, Bernadette Kalman

  • 1Department of Neurology, MCP Hahnemann University, Philadelphia, Pennsylvania, USA.

American Journal of Alzheimer'S Disease and Other Dementias
|February 8, 2002
PubMed
Summary

Multiple sclerosis (MS) patients frequently experience cognitive impairment (CI), affecting memory, attention, and processing speed. Early MS treatment can mitigate neurological and cognitive decline.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Somatic Mutations in Nuclear and Mitochondrial Genes of Mitochondrial Proteins in Primary and Recurrent Glioblastoma.

International journal of molecular sciences·2026
Same author

The Contribution of Paresis, Age, and the Effect of Short Training on Cognitive-Motor Dual-Task Interference After Stroke: A Pilot Study.

Life (Basel, Switzerland)·2025
Same author

Using Whole Exome Sequencing to Identify Genetic Causes of Neurodevelopmental Disorders in a Cohort of 11 Patients: A Single Center Experience.

International journal of molecular sciences·2025
Same author

[A rare clinical presentation of a patient with Blau syndrome confirmed by genetic analysis].

Orvosi hetilap·2025
Same author

Global Presence and Penetrance of <i>CSF1R</i>-Related Disorder.

Neurology. Genetics·2024
Same author

[Relationship between the vitamin D supply and some protein fractions in patients with chronic kidney disease].

Orvosi hetilap·2024

Area of Science:

  • Neuroscience
  • Neurology
  • Immunology

Background:

  • Multiple sclerosis (MS) is a central nervous system (CNS) inflammatory demyelinating disease.
  • Cognitive impairment (CI) affects 45-65% of MS patients, irrespective of physical disability.
  • CI in MS manifests as bradyphrenia, attention deficits, memory retrieval issues, and language impairments.

Purpose of the Study:

  • To summarize the prevalence and characteristics of cognitive impairment in multiple sclerosis.
  • To explore the relationship between MS pathology and cognitive deficits.
  • To discuss potential therapeutic strategies for managing cognitive dysfunction in MS.

Main Methods:

  • Comprehensive neuropsychological studies.
  • Analysis of magnetic resonance imaging (MRI) for disease burden.

Related Experiment Videos

  • Review of pathological mechanisms including inflammation and pathway disruption.

    • Main Results:

    • Cognitive impairments span multiple domains including speed, attention, memory, and language.
    • Severity of CI correlates with the total brain disease burden (microscopic and macroscopic).
    • Disruption of neural pathways and inflammatory products contribute to neuronal dysfunction.

    Conclusions:

    • Early MS treatment with interferons and copaxone can reduce neurological and cognitive disability.
    • Neuropsychological screening and cognitive rehabilitation are crucial for MS patient care.
    • Development of neuroprotective agents is needed for more effective management.