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Related Experiment Videos

The existing interim consensus reference ranges and the future approach.

F Dati1, A M Johnson, J T Whicher

  • 1QM-Lab, TUV Rheinland Berlin-Brandenburg, Cologne, Germany. dati@de.tuv.com

Clinical Chemistry and Laboratory Medicine
|February 8, 2002
PubMed
Summary
This summary is machine-generated.

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The 1993 release of the CRM 470/RPPHS serum protein reference material improved lab test consistency. However, new reference ranges are needed due to significant shifts in some protein values.

Area of Science:

  • Clinical chemistry
  • Biochemistry
  • Laboratory medicine

Background:

  • The introduction of the CRM 470/RPPHS reference material for serum proteins in 1993 significantly enhanced inter-laboratory measurement consistency.
  • This standardization has led to notable shifts in established reference values for specific serum proteins.

Purpose of the Study:

  • To address the impact of the new reference material on serum protein measurements.
  • To inform the ongoing establishment of updated reference ranges for clinical use.

Main Methods:

  • Analysis of serum protein measurements following the adoption of CRM 470/RPPHS.
  • Consensus-building among professional societies and diagnostic companies.

Main Results:

Related Experiment Videos

  • Demonstrated improvement in between-laboratory variability for serum protein assays.
  • Identified significant alterations in reference values for certain serum proteins.

    • Conclusions:

    • The CRM 470/RPPHS has successfully reduced variability in serum protein testing.
    • Interim consensus reference ranges are being utilized while new, definitive ranges are established.