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Updated: Aug 19, 2026

Selected Reaction Monitoring Mass Spectrometry for Absolute Protein Quantification
Published on: August 17, 2015
The existing interim consensus reference ranges and the future approach
F Dati1, A M Johnson, J T Whicher
1QM-Lab, TUV Rheinland Berlin-Brandenburg, Cologne, Germany. dati@de.tuv.com
Abstract:
The release of the reference material for serum proteins, CRM 470/RPPHS, in 1993, has given rise to a great improvement in the between-laboratory variability of serum protein measurements worldwide. However, conversion to the new reference material has resulted in significant changes in reference values for some proteins. The establishment of new reference ranges is currently in progress; in the interim, several professional societies and diagnostic companies have agreed to use consensus reference ranges based on studies that were already undertaken.
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