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Related Experiment Videos

Soluble transferrin receptor (sTfR): biological variations and reference limits.

G Raya1, J Henny, J Steinmetz

  • 1Laboratoire de biologie clinique, Centre de Médecine Préventive, Vandoeuvre-lès-Nancy, France.

Clinical Chemistry and Laboratory Medicine
|February 8, 2002
PubMed
Summary

This study established reference limits for soluble serum transferrin receptor (sTfR) in healthy individuals across various age groups. Reference values were determined, considering factors influencing sTfR concentration for accurate clinical interpretation.

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Area of Science:

  • Clinical Biochemistry
  • Hematology
  • Reference Intervals

Background:

  • Soluble serum transferrin receptor (sTfR) is a marker used in assessing iron status and erythropoiesis.
  • Establishing accurate reference limits is crucial for reliable clinical interpretation of sTfR levels.

Purpose of the Study:

  • To determine age- and sex-specific reference limits for soluble serum transferrin receptor (sTfR) in a healthy population.
  • To identify biological and other factors influencing sTfR concentrations.

Main Methods:

  • Measurement of sTfR in 885 healthy subjects aged 3-91 years using an immunonephelometric assay.
  • Analysis of variability and identification of factors (e.g., ferritin, hemoglobin, age, sex, MCV, tobacco use, physical activity) associated with sTfR concentration.

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  • Definition of exclusion and partition criteria based on identified factors to establish reference samples.

    • Main Results:

    • sTfR median concentrations showed a gradual decrease from younger to middle-aged groups, with variations in older females.
    • Interindividual variability ranged from 12.6% to 30.3%, with analytical variability at 5%.
    • Established reference medians stratified by age and sex, with specific values for different groups (e.g., 1.60 mg/l for 3-10 years, 1.16-1.26 mg/l for adults).

    Conclusions:

    • The study successfully established reference limits for sTfR across a wide age range in healthy individuals.
    • Identified key factors influencing sTfR levels, aiding in the refinement of reference value interpretation.
    • The findings provide a basis for accurate assessment of iron status and related conditions using sTfR.