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High sensitivity C-reactive protein (CRP) reference intervals in the elderly.

B Herbeth¹, G Siest, J Henny

¹Laboratoire de biologie clinique, Centre de Médecine Préventive, Vandoeuvre-lès-Nancy, France.

Clinical Chemistry and Laboratory Medicine

|February 8, 2002

Summary

Reference intervals for high-sensitivity C-reactive protein (hs-CRP) were established for older adults. This study determined gender-specific hs-CRP reference ranges for individuals aged 50 and above.

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Area of Science:

Clinical Biochemistry
Geriatric Medicine
Biomarker Research

Background:

High-sensitivity C-reactive protein (hs-CRP) is a key clinical biomarker.
Established hs-CRP reference intervals are lacking for elderly populations.
Accurate reference ranges are crucial for appropriate clinical interpretation.

Purpose of the Study:

To determine reference intervals for hs-CRP in elderly individuals.
To provide age- and gender-stratified hs-CRP reference limits.
To support accurate hs-CRP interpretation in geriatric care.

Main Methods:

Non-parametric statistical methods were employed.
Reference limits were calculated for distinct age groups (50-64 and 65-91 years).
Analysis considered both male and female participants.

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Main Results:

Reference intervals for hs-CRP were successfully determined for the elderly cohort.
No significant gender-based differences in hs-CRP levels were observed in the study sample.
Age-specific reference ranges were established.

Conclusions:

The study provides essential hs-CRP reference intervals for geriatric populations.
Findings suggest hs-CRP levels are comparable between genders in older adults.
These reference values can aid clinicians in hs-CRP assessment for the elderly.