Related Experiment Video
Updated: Jul 12, 2026

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
Published on: December 28, 2010
Estimating the unbiased estimator theta for population genetic survey data
J J Weicker1, R T Brumfield, K Winker
1University of Alaska Museum, Fairbanks, 99775-6960, USA. weicker@post.harvard.edu
Abstract:
We consider a method of approximating Weir and Cockerham's theta, an unbiased estimator of genetic population structure, using values readily available from published studies using biased estimators (Wright's F(ST) or Nei's G(ST)). The estimation algorithm is shown to be useful for both model populations and real-world avian populations. However, the correlation between Wright's F(ST) and Weir and Cockerham's theta is strong when compared among 39 empirical avian datasets. Thus, the advantage of approximating an unbiased estimator is unclear considering the small actual effect of theta's bias-removing power on empirical datasets.
Related Concept Videos
What are Estimates?
The estimate for the mean of a sample is denoted by ͞x, whereas the mean of the population is designated as μ. Further, parameters such as the mean,...
Distributions to Estimate Population Parameter
Choosing Between z and t Distribution
Estimating Population Standard Deviation
Estimating Population Mean with Unknown Standard Deviation
William S. Gosset (1876–1937) of the Guinness...
Testing a Claim about Mean: Unknown Population SD
Estimating a population mean requires the samples to be approximately normally distributed. The data should be collected from the randomly selected samples having no sampling bias. There is no specific requirement for sample size. But if the sample size is less than 30, and we don't know the population standard deviation, a different approach is used; instead...

