Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug discrimination under concurrent variable-ratio variable-ratio schedules.

D E McMillan1, W C Hardwick, Mi Li

  • 1Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock 72205, USA. mcmillandonalde@uams.edu

Journal of the Experimental Analysis of Behavior
|February 8, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient and family perceptions of a discharge bedside board.

PEC innovation·2023
Same author

In Situ High-Resolution AFM Imaging and Force Probing of Cell Culture Medium-Forming Nanogranular Surfaces for Cell Growth.

IEEE transactions on nanobioscience·2020
Same author

Mn-substituted goethite for uranium immobilization: A study of adsorption behavior and mechanisms.

Environmental pollution (Barking, Essex : 1987)·2020
Same author

Synthesis, Characterization, and Utilization of a Lignin-Based Adsorbent for Effective Removal of Azo Dye from Aqueous Solution.

ACS omega·2020
Same author

Photosensitive inhibition of the GABA system in vitro.

Scientific reports·2020
Same author

Highly oxidized sesquiterpenes from the fruits of Illicium lanceolatum A. C. Smith.

Phytochemistry·2020
Same journal

The Genoeconomics of Impulsive Intertemporal Choice: A Critical Review.

Journal of the experimental analysis of behavior·2026
Same journal

Shaping the extinction burst: Increasing its probability and preventing its emergence across topographies.

Journal of the experimental analysis of behavior·2026
Same journal

Evaluating the combined effects of effort and probability on monetary discounting.

Journal of the experimental analysis of behavior·2026
Same journal

An improved translational approach to studying persistence-strengthening effects of differential reinforcement of alternative behavior.

Journal of the experimental analysis of behavior·2026
Same journal

Interactions between the effects of food and water motivating operations on concurrent food- and water-reinforced responding in mice.

Journal of the experimental analysis of behavior·2026
Same journal

Odor-visual and visual-visual matching to sample with dogs.

Journal of the experimental analysis of behavior·2026
See all related articles

Pigeons learned to distinguish pentobarbital from saline using concurrent variable-ratio schedules. Drug discrimination dose-response curves under these schedules were graded, unlike those seen with fixed-ratio schedules.

Area of Science:

  • Behavioral pharmacology
  • Animal models of drug effects
  • Operant conditioning

Background:

  • Drug discrimination studies are crucial for understanding how drugs affect behavior.
  • Concurrent variable-ratio (VR) schedules are used to study choice behavior and reinforcement.

Purpose of the Study:

  • To investigate drug discrimination using concurrent VR-VR schedules.
  • To characterize dose-response curves for various drugs under these schedules.

Main Methods:

  • Pigeons were trained to discriminate pentobarbital from saline under concurrent VR-VR schedules.
  • Different doses of pentobarbital and other drugs were tested.
  • Response patterns and generalization curves were analyzed.

Main Results:

Related Experiment Videos

  • Pigeons predominantly chose the option with lower response requirements.
  • Low doses of tested drugs led to saline-biased responding; higher doses shifted towards pentobarbital-biased responding for some drugs.
  • Generalization curves were typically graded, not quantal.

Conclusions:

  • Drug discrimination is feasible under concurrent VR-VR schedules.
  • The graded dose-response curves observed resemble those from interval schedules, not fixed-ratio schedules.
  • Graded curves may reflect probability matching or difficulties in discriminating reinforcement frequency differences.