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[Changes of endometrial macrophages and nature kill cells during luteal phase and early pregnancy]
1Department of Gynecology and Obstetrics, Renji Hospital, Shanghai Second University, Shanghai 200001, China.
Objective:
To investigate the effect of endometrial microenvironment on pregnancy.
Methods:
The number of macrophage and nature kill (NK) cells in decidua and endometrium were determined in 19 cases of early pregnancy and 11 non-pregnant women respectively by cytometric analysis.
Results:
The percentages of macrophages (leukocyte antigen molecules CD14 positive) and NK cells (CD56 positive) were significantly increased in decidua of first trimester as compared with those in luteal endometrium (P < 0.01). The number of CD(56)(+)CD(16)(-) subset of NK cells increased significantly during early pregnancy. While the number of CD(56)(+)CD(16)(+) subset did not change.
Conclusion:
The endometrial macrophages and NK cells may be involved in the mechanism of the fetal protective immune reaction during pregnancy.