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[Effects of estrogen on experimental tooth movement in osteoporosis rats]
1Department of Orthodontic, College of Stomatology, Fourth Military Medical University, Xi'an 710032, China.
Objective:
To investigate the effects of estrogen on the orthodontic tooth movement and alveolar bone in osteoporosis rats.
Methods:
Thirty 3 month-old female sprague-dawley rats were divided randomly into three groups (control, osteoporosis and estrogen). In the three groups, the distances of tooth movement and the number of osteoclast were measured and compared. Histologic changes were observed.
Results:
Compared with the control group, in first month, the distances of orthodontic tooth movement was increased by 43.3% in osteoporosis group and by 30.7% in estrogen group; the number of osteoclast was increased by 64.4% and by 32.9% respectively. In second month, the distances were increased by 68.5% in osteoporosis group and by 24.9% in estrogen group; the number of osteoclast was increased by 68.7% and by 15.0% respectively. In addition, estrogen promoted the alveolar bone-forming and inhibited the bone resorption.
Conclusion:
It is suggested that the estrogen may affect the rate of orthodontic tooth movement on postmenopausal osteoporosis patient.
