Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Tissue engineered neo-cartilage using polymer substrates and chondrocytes: experimental study].

C Wang1, X Yuan, S Liu

  • 1Institute of Basic Medical Science, Academy of Military Medical Science, Beijing 100850, China.

Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|February 8, 2002
PubMed
Summary

Poly beta-hydroxybutyrate (PHB) foam serves as an effective scaffold for chondrocytes, enabling the generation of new cartilage tissue. This study demonstrates PHB

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The platelet-derived growth factor alpha-receptor is encoded by a growth-arrest-specific (gas) gene.

Proceedings of the National Academy of Sciences of the United States of America·1996
Same author

Data from men in greater Seattle area reveals no downward trend in semen quality: further evidence that deterioration of semen quality is not geographically uniform.

Fertility and sterility·1996
Same author

Microsatellite instability in transitional cell carcinoma of the urinary tract and its relationship to clinicopathological variables and smoking.

International journal of cancer·1996
Same author

Sexual dimorphism of cardiovascular responses to early blockade of bradykinin receptors.

Hypertension (Dallas, Tex. : 1979)·1996
Same author

Rate-determining steps for tyrosine phosphorylation by the kinase domain of v-fps.

Biochemistry·1996
Same author

Cell-type-specific expression of the platelet-derived growth factor alpha receptor: a role for GATA-binding protein.

Molecular and cellular biology·1996

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Orthopedic Research

Context:

  • Cartilage defects pose significant clinical challenges.
  • Current treatments for cartilage damage have limitations.
  • Tissue engineering offers a promising alternative for cartilage repair.

Purpose:

  • To evaluate poly beta-hydroxybutyrate (PHB) as a scaffold for chondrocytes.
  • To assess the feasibility of generating engineered cartilage in a rabbit model.

Summary:

  • Chondrocytes were seeded onto PHB scaffolds and implanted in rabbits.
  • New cartilage formation was observed in PHB-chondrocyte constructs.
  • Control groups (PHB alone or chondrocytes alone) showed no cartilage formation.

Related Experiment Videos

Impact:

  • PHB foam is a suitable matrix for cartilage tissue engineering.
  • PHB scaffolds support chondrocyte seeding and new cartilage generation.
  • This approach holds potential for reconstructive surgery applications.