[Expression and significance of AR in osteosarcoma]

To determine the relationship between AR and pathological characteristics of osteosarcoma and to investigate the potential role of AR in the pathogenesis of osteosarcoma.

AR in the samples of the paraffin embedded tissues from 65 cases of osteosarcoma was immunohistochemically detected by streptavidin/peroxidase (SP) method. The pathology of osteosarcoma was classified and graded according to Liu Zijun's Classification.

The positive rate of AR was 50.8% (33/65). The positive particles were distributed in the cytoplasm and nucleus. The positive rate of AR in osteosarcoma with higher grade of cell differentiation was lower than that in the tumor with lower one. There was no significant difference in different pathological type of osteosarcoma.

AR exists in osteosarcoma and its positive rate is related to the cell differentiation of osteosarcoma.