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[Troponin T during cardiopulmonary bypass]
Objective:
To evaluate the effect of cardiopulmonary bypass (CPB) on myocardial troponin T and its clinical significance and relationship to myocardial cell injury.
Methods:
Thirty-seven patients underwent open heart surgery under CPB. The procedures included correction of congenital heart disease in 15 patients, valve replacement in 15, and coronary artery bypass grafting in 7. Blood samples were taken at four different time intervals for assessing a troponin T. Correlative factors including duration of clamping of aorta, dosage of cardioplegic solution, and metabolic acidosis were studied.
Results:
When clamping time > 60 minutes, dosage of cardioplegia solution < 10 ml/kg and existing metabolic acidosis, the level of troponin T was significantly increased (P < 0.01).
Conclusion:
The elevation of troponin T is closely related to cardiopulmonary bypass, especially the duration of clamping of aorta, insufficiency of cardioplegia, and metabolic acidosis.