Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Repairing peripheral nerve defects by tissue engineering techniques:an experimental study].

C Dai1, Q Shang, W Wang

  • 1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.

Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|February 8, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precise Measurement of the Chromoelectric Dipole Moment of the Charm Quark.

Physical review letters·2026
Same author

Precise Measurement of Matter-Antimatter Asymmetry with Entangled Hyperon-Antihyperon Pairs.

Physical review letters·2026
Same author

Observation of Λ[over ¯]p→K^{+}π^{+}π^{-}π^{0} and Λ[over ¯]p→K^{+}π^{+}π^{-}2π^{0}.

Physical review letters·2026
Same author

First Measurement of the D_{s}^{+}→K^{0}μ^{+}ν_{μ} Decay.

Physical review letters·2026
Same author

Observation of the Electromagnetic Radiative Decays of the Λ(1520) and Λ(1690) to γΣ^{0}.

Physical review letters·2026
Same author

Observation of a Threshold Enhancement in the π^{+}π^{-} Spectrum in ψ(3686)→π^{+}π^{-}J/ψ Decays.

Physical review letters·2026
Same journal

[Surgical rescue for severe acute pancreatitis complicated by infected and pancreatic necrosis sepsis: a clinical practice analysis].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026
Same journal

[Analysis of adjuvant chemotherapy efficacy based on GLUT1 expression levels after radical resection of pancreatic cancer].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026
Same journal

[Safety and efficacy of bovine pericardial patch wrapping of the hepatic artery for preventing delayed postpancreatectomy hemorrhage after laparoscopic pancreaticoduodenectomy].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026
Same journal

[Application of the "2+3" pancreaticojejunostomy in 110 cases of pancreaticoduodenectomy].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026
Same journal

[Blood flow control techniques in pancreatic surgery].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026
Same journal

[Arterial variations and management strategies in pancreatic surgery].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026
See all related articles

This study developed a tissue-engineered scaffold using Schwann cells (SCs) and polyglycolic acid (PGA) fibers to repair peripheral nerve gaps. The novel scaffold demonstrated promising functional recovery comparable to nerve autografts in rats.

Area of Science:

  • Biomaterials Science
  • Neuroscience
  • Tissue Engineering

Context:

  • Peripheral nerve injuries often result in significant functional deficits.
  • Repairing long nerve gaps remains a clinical challenge.
  • Autologous nerve grafts are the gold standard but have limitations.

Purpose:

  • To develop and evaluate a novel tissue-engineered scaffold for peripheral nerve gap repair.
  • To assess the efficacy of Schwann cells (SCs) integrated with polyglycolic acid (PGA) fibers.
  • To compare the functional and histological outcomes with autologous nerve grafts.

Summary:

  • Expanded Schwann cells were inoculated onto bio-absorbable polyglycolic acid (PGA) fibers to create tissue-engineered scaffolds.
  • These scaffolds successfully bridged a 15 mm sciatic nerve gap in Wistar rats.

Related Experiment Videos

  • Histological analysis showed SCs formed Büngner's band-like structures and secreted laminin, promoting regeneration.

    • Impact:

    • The developed scaffold shows potential as an effective substitute for peripheral nerve repair.
    • Functional recovery in scaffold-treated rats was comparable to nerve autografts.
    • This approach offers a promising solution for bridging long peripheral nerve gaps, potentially improving patient outcomes.