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[Postoperative recurrence of T2 stage gastric cancer]
1Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
Objective:
To study the clinicopathological characteristics of T(2) gastric cancer and its postoperative recurrence.
Method:
124 T(2) gastric cancer patients were divided into two groups: 42 patients with postoperative recurrence (Group 1) and 82 patients without recurrence (Group 2).
Results:
The recurrence rate of local tumor was significantly lower in Group 1 (26.2%) than in Group 2 (45.1%). Deep invasion was highly different between the two groups. Circular muscle tumors were seen in Group 1 (4.8%) and in Group 2 (30.5%), whereas sub-serosa tumors were seen in Group 1 (61.8%) and in Group 2 (25.6%). The rate of lymph node metastasis was significantly higher in Group 1 (88.1%) than in Group 2 (57.3%). The mean number of positive nodes was (7.02 +/- 6.50) in Group 1 and (2.16 +/- 2.04) in Group 2(P < 0.01). Local recurrence rate and distant metastasis rate in Group 1 were 54.8% and 46.2% respectively. The median survival was 26.5 months in Group 1 and 57.0 months in Group 2 (P < 0.01). The 1-, 3-, 5-year survival rate in Group 1 and Group 2 were 61.4% vs 97.6%, 18.7% vs 95.9%, and 8.3% vs 95.9%, respectively.
Conclusion:
Poor prognosis is seen in T(2) gastric cancer patients with postoperative recurrence. Extended gastrectomy and multi-therapy are necessary for the patients with the risk factors so as to decrease local recurrence.