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Updated: Jul 13, 2026
Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
Published on: April 28, 2013
[Acoustic densitometry for quantification of renal allografts microcirculation and microstructure]
1Department of Utrasound, General Hospital, People Liberation Army, Beijing 100853, China.
Objective:
To establish a new method for observing renal allografts microcirculation and microstructure with acoustic densitometry (integrated backscatter, contrast, second harmonics).
Methods:
27 patients with renal allografts were investigated by Doppler, IBS, contrast and second harmonics. Renal allografts failed age in 5 patients 20-61 years. Intravenous injection of SHU-508A was given, compared with pre-injection by quantitative assessment of acoustic densitometry (AD) of renal microstructure.
Results:
There was a significant difference in the peak intensity, the area under the curve and the half-time of wash-out between pre-injection and injection contrast agent. The wish-in and wish-out curve was shown in a peak shape. The renal allografts with acute rejection were significantly lower than the control group in AD (P < 0.05). No contrast opacification of renal microstructure was present in 5 failed renal allografts and the wish-in and wish-out curve appeared in a straight line shape.
Conclusion:
AD is safe, and efficient in assessing renal allografts microstructure. It more sensitive in detecting allograft complication such as rejection than Doppler.
