Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Winging it--actin on the fly.

Buzz Baum1

  • 1LICR, Department of Biochemistry and Molecular Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom.

Developmental Cell
|February 8, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

3D epithelial cell topology tunes signaling range to promote precise patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Molecular structure of the ESCRT-III-based archaeal CdvAB cell division machinery.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

The mechanism of cell-cycle-dependent proteasomal degradation of archaeal ESCRT-III homolog CdvB in Sulfolobus.

The EMBO journal·2026
Same author

Temporal and spatial coordination of DNA segregation and cell division in an archaeon.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

High-throughput mechanomic screening reveals novel regulators of single-cell mechanics.

Biophysical journal·2025
Same author

Balancing stability and flexibility when reshaping archaeal membranes.

eLife·2025
Same journal

AXIN1 and AXIN2 regulate the WNT-signaling landscape to promote distinct mesoderm programs.

Developmental cell·2026
Same journal

ARID1A terminates gastric regeneration to prevent cancer.

Developmental cell·2026
Same journal

Myc sustains sex-biased organ zonation in the Drosophila intestine.

Developmental cell·2026
Same journal

Two parallel neuronal circuits involving electrical synapse and DAF-7/TGF-β signaling regulate muscle autophagy in C. elegans.

Developmental cell·2026
Same journal

Menstruation: Once unspoken but now uncovered, one cell type at a time.

Developmental cell·2026
Same journal

The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair.

Developmental cell·2026
See all related articles

The Slingshot protein regulates actin dynamics, a key process in cell structure formation. This cofilin phosphatase is crucial for controlling the development of Drosophila wing hair.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Molecular Biology

Background:

  • Actin dynamics are essential for cellular structure formation during development.
  • Regulation of actin dynamics is critical for morphogenesis.
  • The precise mechanisms controlling actin dynamics remain incompletely understood.

Purpose of the Study:

  • To investigate the role of the conserved cofilin phosphatase, Slingshot, in modulating actin dynamics.
  • To understand how Slingshot influences cellular structure development.
  • To elucidate the contribution of Slingshot to Drosophila wing hair morphogenesis.

Main Methods:

  • Utilized Drosophila melanogaster as a model organism.
  • Investigated the function of Slingshot through genetic and molecular approaches.

Related Experiment Videos

  • Analyzed actin dynamics and wing hair development.

    • Main Results:

    • Identified Slingshot as a conserved cofilin phosphatase.
    • Demonstrated that Slingshot modulates actin dynamics.
    • Showed Slingshot plays a role in controlling Drosophila wing hair morphogenesis.

    Conclusions:

    • Slingshot is a key regulator of actin dynamics.
    • Slingshot's phosphatase activity is important for cellular morphogenesis.
    • Understanding Slingshot function provides insights into developmental processes.