Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rofecoxib-associated upper gastrointestinal bleed: a case report.

Gordon M Freedman1, Joel M Kreitzer, Ruchi Badola

  • 1Pain Management Service, Box 1192, Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029, USA.

The Mount Sinai Journal of Medicine, New York
|February 8, 2002
PubMed
Summary

This report details the first known case of upper gastrointestinal bleeding linked to rofecoxib. Caution is advised when prescribing rofecoxib to patients at risk for peptic ulcer disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unraveling Population Trend of a Critically Endangered Freshwater Crocodylian, Gharial (<i>Gavialis gangeticus</i>) in the National Chambal Sanctuary, India.

Ecology and evolution·2025
Same author

Genome Assembly of Gangetic Dolphin (Platanista gangetica) Reveals Signature of Regressive Evolution.

Genome biology and evolution·2025
Same author

Unveiling the contemporary genetic diversity and population demography of the critically endangered northern river terrapin (Batagur baska) in the sundarbans.

Molecular biology reports·2025
Same author

Assessing the implications of habitat transformations on human-large carnivore interactions outside protected areas.

Scientific reports·2025
Same author

GIS and AHP-based methods for river risk zone (RRZ) assessment: a case study of the Himalayan rivers in Doon Valley, Uttarakhand, India.

Environmental science and pollution research international·2025
Same author

Do dietary exposures to multi-class endocrine disrupting chemicals translate into health risks for Gangetic dolphins? An assessment and way forward.

Heliyon·2024

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Rofecoxib is a selective COX-2 inhibitor used for pain and inflammation.
  • Peptic ulcer disease (PUD) is a common gastrointestinal condition.

Observation:

  • This clinical report describes a patient experiencing upper gastrointestinal hemorrhage.
  • The hemorrhage was associated with rofecoxib use.

Findings:

  • This is the first documented instance of rofecoxib-induced upper gastrointestinal bleeding.
  • The patient presented with symptoms of significant gastrointestinal bleeding.

Implications:

  • Clinicians should exercise caution when prescribing rofecoxib, especially in patients with PUD risk factors.
  • A maximum daily dose of 25 mg of rofecoxib is recommended for high-risk individuals to mitigate bleeding risk.

Related Experiment Videos