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Updated: Aug 18, 2026

Small Bowel Transplantation In Mice
Published on: August 20, 2007
The management of patients with the short bowel syndrome
Cameron F E Platell1, Jane Coster, Rosalie D McCauley
1Department of Surgery, The University of Western Australia, Perth, Australia. cplatell@cyllene.uwa.edu.au
Abstract:
The surgeon is invariably the primary specialist involved in managing patients with short bowel syndrome. Because of this they will play an important role in co-ordinating the management of these patients. The principal aims at the initial surgery are to preserve life, then to preserve gut length, and maintain its continuity. In the immediate postoperative period, there needs to be a balance between keeping the patient alive through the use of TPN and antisecretory agents and promoting gut adaptation with the use of oral nutrition. If the gut fails to adapt during this period, then the patient may require therapy with more specific agents to promote gut adaptation such as growth factors and glutamine. If following this, the patient still has a short gut syndrome, then the principal options remain either long term TPN, or intestinal transplantation which remains a difficult and challenging procedure with a high mortality and morbidity due to rejection.
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