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Chromosomal imbalances identified by comparative genomic hybridization in sporadic parathyroid adenomas
Juan Luis Garcia1, Juan C Tardio, Norma Carmen Gutierrez
1Centro de Investigacion del Cancer, Universidad de Salamanca-CSIC, Salamanca, Spain.
Objective:
To identify chromosomal gains and losses in sporadic parathyroid adenomas (PAs).
Methods:
Fourteen sporadic PAs were studied by comparative genomic hybridization (CGH).
Results:
The fourteen studied PAs showed chromosomal imbalances. All cases except one exhibited two or more abnormalities. Chromosomal gains were found in all cases, and three cases (21%) also presented chromosomal losses. Genomic amplification was not observed. Chromosome 9 was involved in ten cases. Recurrent genetic gain was found on 9p22-24 and on 9q34, each in 6 of 14 cases (43%). Other recurrent gains included Xq26 in 6 PAs (43%) and 4q21-28 and 8p22-23, each in 4 of 14 cases (29%). Regions of recurrent genetic loss involved whole chromosome 11 and 20q12-13, each in 2 of 14 cases (14%).
Conclusions:
Our findings show chromosomal imbalances in all sporadic PAs studied by CGH, partly confirming previous reports, with the exception that we observed more chromosomal gains than losses. Several regions (9p22-24, 9q34, Xq26, 4q21-28, and 8p22-23) probably deserve further investigation in order to discard the presence of genes involved in parathyroid tumorigenesis.