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Severe obstructive sleep apnea is associated with left ventricular diastolic dysfunction.

Jeffrey W H Fung1, Thomas S T Li, Dominic K L Choy

  • 1Division of Cardiology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.

Chest
|February 9, 2002
PubMed
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Diastolic dysfunction is common in obstructive sleep apnea (OSA) patients. Lower oxygen saturation during sleep independently predicts this dysfunction, indicating severe OSA impacts heart function.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Pulmonology

Background:

  • Hypertension is prevalent in patients with obstructive sleep apnea (OSA).
  • The impact of OSA on ventricular function, particularly diastolic function, remains unclear.
  • This study investigates diastolic dysfunction in OSA patients and its relation to OSA severity.

Purpose of the Study:

  • To determine the prevalence of diastolic dysfunction in patients with OSA.
  • To explore the relationship between diastolic parameters and the severity of OSA.
  • To identify predictors of diastolic dysfunction in OSA patients.

Main Methods:

  • Sixty-eight OSA patients underwent polysomnography and echocardiography.
  • Left ventricular diastolic function was assessed using transmitral valve pulse-wave Doppler echocardiography.

Related Experiment Videos

  • Baseline characteristics, OSA severity (apnea/hypopnea index - AHI), and echocardiographic parameters were compared.

    • Main Results:

    • Diastolic dysfunction (abnormal relaxation pattern - ARP) was found in 36.8% of patients.
    • Older age, hypertension, and lower minimum oxygen saturation (SpO2) during sleep were associated with ARP.
    • Minimum SpO2 < 70% was an independent predictor of ARP (OR 4.34).
    • Patients with AHI >= 40/h showed significantly longer isovolumic relaxation times.

    Conclusions:

    • Diastolic dysfunction, specifically ARP, is common in OSA patients.
    • More severe OSA is linked to increased left ventricular diastolic dysfunction.
    • Minimum SpO2 is a key indicator for diastolic dysfunction in OSA.