Related Experiment Videos
Airway hyperresponsiveness and calcium handling by smooth muscle: a "deeper look"
Krishnan Parameswaran1, Luke J Janssen, Paul M O'Byrne
1Asthma Research Group, Department of Medicine, St. Joseph's Healthcare & McMaster University, Hamilton, ON, Canada.
Chest
|February 9, 2002
Abstract:
We propose that abnormal calcium handling by the airway smooth muscle may be an important determinant of airway hyperresponsiveness. The amplitude, frequency, or localization of Ca(2+) oscillations in the smooth muscle may determine the degree of airway sensitivity and reactivity, which are characteristic features of asthma.