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Related Experiment Videos

Coagulation changes in individuals with sickle cell trait.

M P Westerman1, D Green, A Gilman-Sachs

  • 1Department of Medicine, Mount Sinai Hospital Medical Center, Chicago, Illinois 60608, USA. wesm@sinai.org

American Journal of Hematology
|February 9, 2002
PubMed
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Individuals with sickle cell trait (Hb AS) show increased coagulation activity, indicated by higher d-dimers, thrombin-antithrombin complexes, and prothrombin fragment 1.2 levels. This activation is less severe than in sickle cell disease but suggests a hypercoagulable state.

Area of Science:

  • Hematology
  • Coagulation Science
  • Genetics

Background:

  • Sickle cell disorders (Hb SS, Hb SC) are linked to hypercoagulability and vaso-occlusive events.
  • The extent of coagulation activity in sickle cell trait (Hb AS) is not well-understood.
  • Clarifying coagulation in Hb AS may illuminate sickle cell disease pathophysiology.

Purpose of the Study:

  • To investigate the degree of increased coagulation activity in individuals with sickle cell trait (Hb AS).
  • To compare coagulation markers in Hb AS individuals with healthy controls (Hb AA) and those with sickle cell disease (Hb SC, Hb SS).

Main Methods:

  • Measured coagulation markers: d-dimers, thrombin-antithrombin (TAT) complexes, prothrombin fragment 1.2 (F1.2).
  • Assessed absolute blood monocyte counts and levels of proteins C and S.

Related Experiment Videos

  • Screened for antiphospholipid antibodies in Hb AS individuals and Hb AA controls.

    • Main Results:

    • Hb AS individuals exhibited significantly elevated d-dimers, TAT complexes, and F1.2 compared to Hb AA controls.
    • Absolute blood monocyte levels were also increased in the Hb AS group.
    • Coagulation markers and monocyte counts showed a progressive increase across genotypes: Hb AA < Hb AS < Hb SC < Hb SS.

    Conclusions:

    • Individuals with sickle cell trait (Hb AS) demonstrate heightened coagulation activity, with d-dimers, TAT, and F1.2 as key indicators.
    • Coagulation activation in Hb AS is less pronounced than in sickle cell disease (Hb SC, Hb SS).
    • Monocytosis and associated hypercoagulability in sickle cell genotypes appear to correlate with disease severity.