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Updated: Oct 2, 2026

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
10:52

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence

Published on: December 23, 2022

Infective endocarditis resulting from CardioSEAL closure of a patent foramen ovale

Jeffrey A Goldstein1, Michael A Beardslee, Haodong Xu

  • 1Division of Cardiovascular Medicine, Barnes-Jewish Hospital, Washington University School of Medicine, 660 South Euclid Ave., Saint Louis, MO 63110, USA. jgoldste@im.wustl.edu

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|February 9, 2002
PubMed

Insights

Patent foramen ovale and atrial septal aneurysm increase stroke risk. This case report details the first instance of endocarditis linked to a CardioSEAL device used for patent foramen ovale closure.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Device Technology

Background:

  • Patent foramen ovale (PFO) and atrial septal aneurysm (ASA) are linked to higher risks of cryptogenic stroke and recurrent thromboembolic events.
  • Percutaneous closure offers an alternative to medical management and surgical intervention for PFO and ASA.
  • Device closure is a recognized treatment modality for specific cardiac septal defects.

Observation:

  • This report describes a rare complication following percutaneous closure of a PFO.
  • The complication observed was endocarditis, an infection of the heart lining.
  • The specific device implicated in this case was the CardioSEAL device.

Findings:

  • The study presents the first documented case of endocarditis associated with a CardioSEAL device.
  • This finding highlights a potential, albeit infrequent, risk associated with PFO closure devices.
  • The case underscores the importance of monitoring for infectious complications post-procedure.

Implications:

  • This case suggests a need for vigilance regarding infectious complications after PFO closure with devices like CardioSEAL.
  • Further research may be warranted to understand the incidence and risk factors for endocarditis in patients undergoing PFO device closure.
  • Clinicians should consider this potential complication when evaluating patients with PFO and relevant symptoms.

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