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Effects of nimodipine on changes of endothelin after head injury in rabbits
1Department of Neurosurgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Objective:
To investigate the effects of nimodipine on changes of endothelin after head injury.
Methods:
Sixty-five adult rabbits were randomized into an injury group (IG, n=30), a nimodipine-treatment group (NTG, n=30) and a control group (CG, n=5). With their heads unfixed, the animals in IG and NTG were injured in the frontal-parietal zone with BIM-II bioimpact. Blood samples and brain tissue were collected before and after injury. The endothelin level was measured with RIA.
Results:
The endothelin level in plasma and brain tissue was significantly increased 24 hours after injury. At the 8th or/and 24th hours postinjury, the endothelin level was significantly lower in NTG than that in IG.
Conclusions:
Nimodipine can prevent endothelin from elevation and act as a practical endothelin antagonist after head injury clinically.
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