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[An experimental study of anti-angiogenesis with a cartilage-derived inhibitor]
1Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai 200003.
[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology
|February 12, 2002
Abstract
Objective:
To evaluate the efficacy of a cartilage-derived inhibitor for the treatment of corneal neovascularization in vivo.
Methods:
A cartilage-derived inhibitor (CDI) from bovine scapula was purified to homogeneity. By rabbit corneal neovascularization (CNV) model, the effect of inhibition of CDI under various conditions was determined in corneal micropocket analysis.
Results:
The purified CDI could inhibit strongly the growing speed and area of rabbit CNV compared to control (P < 0.001).
Conclusion:
It is demonstrated that CDI is a potent dose-dependent inhibitor of angiogenesis.