Related Experiment Video
Updated: Aug 14, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
Published on: April 25, 2016
[Effect of corticosteroids on the enzymatic activity of hepatic tissue]
Abstract:
Tests conducted with rats demonstrated that hydrocortisone and desoxycorticosterone-acetate (DOCA) manifest an effect close by its orientation with regard to mitochondrial and extramitochondrial forms of aspartate- and alanine-aminotransferase (ACT and ALT), as well as cytoplasmatic malate-dehydrogenase (MDG) of the liver. It was only mitochondrial MDG that lent itself to be inhibited by hydrocortisone, but it was induced by DOCA. Adrenalectomy resulted in inhibition on ALT and MDG and in activation of ACT and of mitochondrial LDG. A course-wise introduction of sulphapyridazine with an excess of deficiency of corticosteroids changed the effects of hydrocortisone with respect to cytoplasmatic LDG, as well as the effects of DOCA or adrenalectomy in regard to LDG and MDG.
Related Concept Videos
Hepatic Drug Excretion: Influencing Factors
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Cushing Syndrome II: Pathophysiology

