Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid hormones, brain function and cognition: a brief review.

Jeremy W Smith1, A Tudor Evans, B Costall

  • 1Postgraduate Studies in Neuropharmacology, School of Pharmacy, University of Bradford, Bradford BD7 1DP, UK.

Neuroscience and Biobehavioral Reviews
|February 12, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Behavioural characterization of neuroleptic properties in the rodent.

Proceedings of the Royal Society of Medicine·2010
Same author

Neurochemical aspects of the opioid-induced 'catatonia'.

Neurochemistry international·2010
Same author

Gestational stress induces post-partum depression-like behaviour and alters maternal care in rats.

Psychoneuroendocrinology·2003
Same author

Mobile phone use facilitates memory in male, but not female, subjects.

Neuroreport·2003
Same author

Modulation of 5-HT4 receptor function in the rat isolated ileum by fluoxetine: the involvement of endogenous 5-hydroxytryptamine.

British journal of pharmacology·2002
Same author

Chronic aspirin ingestion improves spatial learning in adult and aged rats.

Pharmacology, biochemistry, and behavior·2002

Thyroxine (L-T4) treatment significantly improved spatial learning and memory in rats. This thyroid hormone enhanced cognitive function and counteracted memory impairment, likely by boosting cholinergic activity.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Pharmacology

Background:

  • Thyroid hormones (THs) are crucial for central nervous system development and function.
  • THs exhibit inter-reliance with neurotransmitters like acetylcholine (Ach) and factors influencing hippocampal function.
  • Spatial learning tasks heavily rely on cholinergic activity and hippocampal integrity.

Purpose of the Study:

  • To investigate the effects of thyroxine (L-T4) on spatial learning performance.
  • To determine if L-T4 influences cognitive function and cholinergic activity in the brain.
  • To assess L-T4's impact on scopolamine-induced cognitive deficits.

Main Methods:

  • Rats received sub-chronic (4 days) or chronic (28 days) L-T4 treatments.
  • Cognitive performance was evaluated using a spatial water maze task.

Related Experiment Videos

  • Scopolamine was administered to induce cognitive deficits; acetylcholinesterase (AChE) activity was measured in brain tissues.

    • Main Results:

    • Both sub-chronic and chronic L-T4 treatments significantly enhanced spatial learning in rats.
    • L-T4 administration mitigated the cognitive-impairing effects of scopolamine.
    • Treated animals showed significantly increased cholinergic activity in the frontal cortex and hippocampus.

    Conclusions:

    • L-T4 administration augments cognitive function, particularly spatial learning and memory.
    • Enhanced cholinergic activity in the brain may mediate L-T4's cognitive benefits.
    • These findings suggest a potential role for thyroid hormone levels in cognitive health and decline.