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Osteomalacia cured by surgery.

A Furco1, M Roger, B Mouchet

  • 1Department of Internal Medicine, Hauts-Clos Hospital, 101 Avenue Anatole France, 10003 Cedex, Troyes, France

European Journal of Internal Medicine
|February 12, 2002
PubMed
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Oncogenic osteomalacia, a rare condition causing bone pain and weakness, can be triggered by mesenchymal tumors. Surgical removal of the tumor, like a tenosynovial giant cell tumor in this case, led to resolution.

Area of Science:

  • Endocrinology
  • Oncology
  • Orthopedics

Background:

  • Oncogenic osteomalacia is a rare paraneoplastic syndrome.
  • It presents with hypophosphatemia, bone pain, and muscle weakness.
  • Mesenchymal tumors are the typical cause, often benign.

Purpose of the Study:

  • To report a unique case of oncogenic osteomalacia.
  • To highlight the association with a specific tumor type and location.
  • To emphasize the importance of tumor excision for treatment.

Main Methods:

  • Case report of a patient with oncogenic osteomalacia.
  • Diagnostic workup including biochemical tests and imaging.
  • Surgical excision of the causative tumor.

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Main Results:

  • The patient presented with classic symptoms of oncogenic osteomalacia.
  • A small mesenchymal tumor of the tendon sheath of the foot was identified.
  • Complete resolution of symptoms occurred after tumor removal.

Conclusions:

  • Oncogenic osteomalacia can be caused by localized tenosynovial giant cell tumors.
  • Surgical excision is an effective treatment for this syndrome.
  • Early diagnosis and tumor removal are crucial for patient recovery.