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B7 costimulation plays an important role in protection from herpes simplex virus type 2-mediated pathology
Lydia G Thebeau1, Lynda A Morrison
1Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1402 Grand Boulevard, St. Louis, Missouri 63104, USA.
Journal of Virology
|February 12, 2002
Abstract:
We have used mice lacking both B7-1 and B7-2 costimulation molecules (B7KO) to investigate the effects of B7 costimulation on herpes simplex virus type 2 (HSV-2) pathogenesis. B7KO mice infected intravaginally with virulent HSV-2 showed more severe genital and neurologic disease and higher mortality rates than their wild-type counterparts. These results suggest that B7 costimulation molecules play an important role in the development of primary immune responses protective against HSV-2.