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Published on: December 19, 2013

MRI detection of myocardial perfusion defects due to coronary artery stenosis with MS-325

Dara L Kraitchman1, Bennett B Chin, Alan W Heldman

  • 1Departments of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-0845, USA. dara@mri.jhu.edu

Journal of Magnetic Resonance Imaging : JMRI
|February 12, 2002
PubMed
Abstract

Insights

MS-325, an albumin-targeted contrast agent, effectively visualizes myocardial ischemia using magnetic resonance imaging (MRI). This agent aids in detecting perfusion defects by showing prolonged hypoenhancement in ischemic areas.

Area of Science:

  • Cardiovascular Imaging
  • Magnetic Resonance Imaging
  • Myocardial Perfusion Assessment

Background:

  • Myocardial ischemia detection is crucial for diagnosing and managing coronary artery disease.
  • Traditional imaging techniques have limitations in sensitivity and specificity.
  • Novel contrast agents are needed to improve diagnostic accuracy.

Purpose of the Study:

  • To evaluate the diagnostic performance of MS-325, an intravascular, albumin-targeted contrast agent, for visualizing myocardial ischemia using MRI.
  • To compare the efficacy of MS-325 enhanced MRI with established methods like SPECT for myocardial perfusion assessment.

Main Methods:

  • Created left anterior descending coronary artery (LAD) stenosis in pigs to induce myocardial ischemia.
  • Utilized first-pass, contrast-enhanced MRI during dipyridamole stress to detect ischemia.
  • Compared MRI findings with Technetium-99m (Tc-99m) sestamibi single-photon emission computed tomography (SPECT) and measured regional coronary blood flow using microspheres.

Main Results:

  • Successfully induced myocardial ischemia in 8 out of 19 animals, characterized by >40% reduction in stress myocardial blood flow.
  • MRI detected perfusion defects with 92.3% sensitivity (defined as > or =75% reduction in peak myocardial signal intensity).
  • Achieved 85% concordance between MRI and SPECT in identifying perfusion defects, with uniform enhancement observed in mild stenosis cases.

Conclusions:

  • MS-325 demonstrates significant value in visualizing myocardial ischemia via MRI.
  • The agent's albumin-binding property leads to prolonged, persistent hypoenhancement in ischemic myocardial beds, facilitating defect detection.
  • MS-325 enhanced MRI shows promise as a reliable tool for assessing myocardial perfusion defects.

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