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Measurement of renal volumes with contrast-enhanced MRI

Curtis H Coulam1, Donna M Bouley, F Graham Sommer

  • 1Department of Radiology, Stanford University School of Medicine, Stanford, California 94205, USA.

Journal of Magnetic Resonance Imaging : JMRI
|February 12, 2002
PubMed
Abstract

Insights

Magnetic resonance imaging (MRI) accurately measures total renal parenchymal volume. While promising for assessing medullary fraction, MRI precision requires further refinement for clinical application.

Area of Science:

  • Nephrology
  • Radiology
  • Medical Imaging

Background:

  • Accurate assessment of renal volume and composition is crucial for diagnosing and managing kidney diseases.
  • In vivo magnetic resonance imaging (MRI) offers a non-invasive method for evaluating renal structures.

Purpose of the Study:

  • To evaluate the accuracy of in vivo MRI for measuring total renal parenchymal volume.
  • To assess the precision of MRI in determining the renal medullary fraction.

Main Methods:

  • Utilized multiphasic contrast-enhanced 3D MRI on a 1.5-T imager in sixteen pig kidneys.
  • Employed kidney segmentation and signal intensity thresholding for volume and fraction calculations.
  • Validated MRI findings against autopsy-derived reference standards for volume, weight, and medullary fraction.

Main Results:

  • Demonstrated excellent correlation between MRI and autopsy measurements for total renal parenchymal volume (R² = 0.86) and weight (R² = 0.90).
  • MRI-derived medullary fraction (0.120 ± 0.067) showed no significant difference compared to autopsy (0.116 ± 0.025; P = 0.84).

Conclusions:

  • In vivo MRI provides accurate measurements of total renal parenchymal volume.
  • MRI shows potential for assessing renal medullary fraction, though current thresholding algorithms limit precision.

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