Related Experiment Video

Updated: Aug 12, 2026

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
08:22

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

[Reversible myocardial ischemia in hypothyroidism: Case report]

I Quevedo1, L Mosso, J M Domínguez

  • 1Departamentos de Endocrinología, Enfermedades Cardiovasculares, Medicina Nuclear, Facultad de Medicina, Pontificia Universidad Católica de Chile.

Revista Medica De Chile
|February 12, 2002
PubMed

Insights

Hypothyroidism can cause silent myocardial ischemia, a reversible heart condition. Thyroid hormone replacement therapy effectively restored normal heart function and exercise capacity in a hypothyroid patient.

Area of Science:

  • Cardiology
  • Endocrinology

Background:

  • Hypothyroidism is associated with cardiovascular complications.
  • Silent myocardial ischemia in hypothyroid patients is a recognized but less common presentation.

Observation:

  • A 49-year-old male presented with an abnormal exercise electrocardiogram.
  • He had laboratory-confirmed hypothyroidism, asthenia, and voice changes.
  • Thallium myocardial perfusion imaging revealed exercise-induced coronary flow alterations in the left ventricle.

Findings:

  • Thyroid hormone substitution therapy was initiated.
  • Coronary angiography performed three months post-treatment was normal.
  • A six-month follow-up showed normal Thallium perfusion and exercise electrocardiogram results.

Implications:

  • This case highlights the importance of considering thyroid dysfunction in patients with unexplained ischemic changes.
  • Thyroid hormone replacement can reverse myocardial ischemia in hypothyroid individuals.
  • Early detection and treatment of hypothyroidism can prevent potentially serious cardiac events.

More Related Videos

Model of Ischemia and Reperfusion Injury in Rabbits06:11

Model of Ischemia and Reperfusion Injury in Rabbits

Published on: November 3, 2023

A Microscopic 2,3,5-Triphenyltetrazolium Chloride Assay for Accurate and Reliable Analysis of Myocardial Injury11:17

A Microscopic 2,3,5-Triphenyltetrazolium Chloride Assay for Accurate and Reliable Analysis of Myocardial Injury

Published on: November 28, 2025

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...