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Peripheral neuropathy in Leigh's encephalomyelopathy
Developmental Medicine and Child Neurology
|October 1, 1975
Summary
Peripheral neuropathy may help distinguish causes of subacute necrotising encephalopathy. Slow nerve conduction in infants could indicate thiamine triphosphate deficiency versus other causes.
Area of Science:
- Neurology
- Biochemistry
Background:
- Subacute necrotising encephalopathy (SNE) is a rare, severe neurological disorder.
- Peripheral neuropathy is not always present in SNE patients.
Observation:
- This study describes an infant diagnosed with subacute necrotising encephalopathy.
- The infant exhibited slow motor nerve conduction velocities, indicating peripheral neuropathy.
Findings:
- The presence of peripheral neuropathy in SNE may be linked to thiamine triphosphate deficiency.
- Slow nerve conduction velocities suggest a potential diagnostic marker for SNE subtypes.
Implications:
- Peripheral neuropathy presence could differentiate thiamine triphosphate deficiency from other SNE etiologies.
- This finding may guide diagnostic approaches and understanding of SNE pathogenesis.