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2-CdA in the treatment of hairy cell leukaemia
D Abhyankar1, S Bajpai, T Saikia
1Department of Medical Oncology, Tata Memorial Hospital, Mumbai.
The Journal of the Association of Physicians of India
|February 12, 2002
Abstract
Introduction:
Hairy cell leukaemia (HCL) is a rare lymphoproliferative disorder. Treatment options available are splenectomy, interferon, DCF and 2-CdA. 2-CdA is considered to have curative potential as proved by the other studies.
Methods:
We gave 2-CdA in a dose of 0.09/kg/day as a continuous infusion in sixteen patients of hairy cell leukaemia.
Results:
Three patients developed neutropenia post transfusion. At the end of three months all patients were in remission. Two patients relapsed at the median follow-up of 15 months.
Conclusion:
2-CdA in HCL can achieve complete remission, prolonged survival and care as well.