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Calcium supplementation in pre-eclampsia.

M Wanchu1, S Malhotra, M Khullar

  • 1Department of Gynaecology and Obstetrics, Government Medical College, Chandigarh.

The Journal of the Association of Physicians of India
|February 12, 2002
PubMed
Summary

Calcium supplementation did not prevent pre-eclampsia but significantly reduced its severity in a randomized trial. This finding is crucial for understanding pregnancy complications and calcium

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Nutritional Science

Background:

  • Pre-eclampsia is a significant cause of maternal and fetal morbidity.
  • Calcium deficiency has been implicated in the pathogenesis of pre-eclampsia.
  • Understanding the role of calcium supplementation is vital for prenatal care.

Purpose of the Study:

  • To investigate the efficacy of calcium supplementation in preventing pre-eclampsia.
  • To assess the impact of calcium on the incidence and severity of pre-eclampsia.

Main Methods:

  • Prospective, open-label, randomized controlled trial.
  • 100 normotensive primigravidae enrolled before 20 weeks gestation.
  • Intervention: 2g elemental calcium daily from 20 weeks gestation to delivery vs. placebo.

Main Results:

  • No significant difference in the overall incidence of pre-eclampsia between groups (18% vs. 16%).
  • Severe pre-eclampsia incidence was significantly lower in the calcium supplementation group.
  • No differences observed in maternal/fetal side effects or perinatal outcomes.

Conclusions:

  • Calcium supplementation effectively reduces the severity of pre-eclampsia.
  • It does not significantly alter the overall incidence of the condition.
  • Further research may explore optimal calcium dosage and timing for pre-eclampsia management.

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