Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience, such as differences...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Signs of Puberty01:27

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and lactation.
Cellular Adaptation II: Hypertrophy01:26

Cellular Adaptation II: Hypertrophy

Hypertrophy is the increase in the size of individual cells, resulting in the enlargement of a tissue or organ. Unlike hyperplasia, which involves an increase in cell number, hypertrophy is characterized by an increase in cell volume. This process often occurs in response to higher functional demand or hormonal stimulation, leading to the production of more structural proteins and organelles, thereby enhancing the cells' work capacity.There are two primary types of hypertrophy: physiological...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lack of association between gestational age adjusted TSH percentiles and neurodevelopmental outcomes among preterm infants.

Journal of neonatal-perinatal medicine·2022
Same author

Use of Gonadotropin-Releasing Hormone Analogs in Children: Update by an International Consortium.

Hormone research in paediatrics·2019
Same author

GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults.

European journal of endocrinology·2015
Same author

Familial and individual predictors of obesity and insulin resistance in urban Hispanic children.

Pediatric obesity·2015
Same author

Safety of fluticasone propionate cream 0.05% for the treatment of severe and extensive atopic dermatitis in children as young as 3 months.

Journal of the American Academy of Dermatology·2002
Same author

Effect of inhaled corticosteroids on growth.

Pediatrics·2001

Related Experiment Video

Updated: Jul 8, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
11:17

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

Prader-Willi syndrome: how does growth hormone affect body composition and physical function?

A L Carrel1, D B Allen

  • 1Department of Pediatrics, University of Wisconsin Children 's Hospital, Madison 53792, USA. alcarrel@facstaff.wisc.edu

Journal of Pediatric Endocrinology & Metabolism : JPEM
|February 12, 2002
PubMed
Summary

Growth hormone (GH) deficiency is common in children with Prader-Willi syndrome (PWS), causing body composition issues. GH treatment improves growth, body fat, and physical abilities in these children.

More Related Videos

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Related Experiment Videos

Last Updated: Jul 8, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
11:17

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Area of Science:

  • Pediatric Endocrinology
  • Genetics and Metabolic Disorders
  • Growth Hormone Research

Background:

  • Prader-Willi syndrome (PWS) is characterized by growth failure, reduced lean body mass, and increased adipose tissue.
  • These body composition abnormalities in PWS patients resemble those in growth hormone deficiency (GHD).
  • Evidence suggests true GHD in many children with PWS due to diminished GH response and low IGF-I levels.

Purpose of the Study:

  • To evaluate the impact of growth hormone (GH) treatment on body composition and metabolic parameters in children with PWS.
  • To assess the contribution of GHD to the disabilities observed in pediatric PWS.
  • To determine the clinical significance and benefits of GH therapy in this population.

Main Methods:

  • Assessment of body composition (lean body mass, adipose tissue) in children with PWS.
  • Measurement of growth parameters, including linear growth.
  • Evaluation of metabolic effects, physical strength, and agility following GH treatment.

Main Results:

  • GH treatment led to decreased body fat and increased lean body mass in children with PWS.
  • Significant improvements were observed in linear growth, fat utilization, and energy expenditure.
  • Enhancements in physical strength and agility were noted, particularly during the first year of therapy.

Conclusions:

  • Growth hormone deficiency contributes significantly to the disabilities associated with Prader-Willi syndrome.
  • GH therapy offers clinically significant benefits for children with PWS, improving body composition and metabolic function.
  • While improvements are most pronounced initially, prolonged GH treatment remains beneficial for managing PWS-related challenges.