Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Interleukin-2 as a therapeutic agent.

N S Sule¹, R P Nerurkar, S Kamath

¹Department of Pharmacology, TN Medical College and BYL Nair Hospital, Mumbai.

The Journal of the Association of Physicians of India

|February 12, 2002

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Occupational skin disease during the COVID-19 pandemic, as captured in a Dermatology staff clinic in the United Kingdom.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020

Same author

Does prehospital time affect survival of major trauma patients where there is no prehospital care?

Journal of postgraduate medicine·2017

Same author

Effect of adjunctive use of green tea dentifrice in periodontitis patients - A Randomized Controlled Pilot Study.

International journal of dental hygiene·2015

Same author

Radiological approach to a child with hip pain.

Clinical radiology·2013

Same author

Decision support system for diabetic retinopathy using discrete wavelet transform.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine·2013

Same author

Impact of obesity severity and duration on pancreatic β- and α-cell dynamics in normoglycemic non-human primates.

International journal of obesity (2005)·2012

Same journal

Indian Expert Consensus on Allergic Rhinitis in Women: A Modified Delphi Survey.

The Journal of the Association of Physicians of India·2026

Same journal

Systematic Review of Topical Capsaicin 0.075% for the Treatment of Neuropathic Pain: Efficacy, Safety, and Tolerability.

The Journal of the Association of Physicians of India·2026

Same journal

Sodium-Glucose Cotransporter 2 Inhibitors in Kidney Diseases Other Than That Due to Diabetes: Benefits in Composite Renal Outcomes Driven by Immunoglobulin A Nephropathy.

The Journal of the Association of Physicians of India·2026

Same journal

<i>Fasciolopsis buski</i> Diagnosed by Upper Gastrointestinal Endoscopy.

The Journal of the Association of Physicians of India·2026

Same journal

"Academic Overdose" among Healthcare Professionals.

The Journal of the Association of Physicians of India·2026

Same journal

Respiratory Examination for Postgraduate Residents: Unrevealing Expert's Questions and Answers.

The Journal of the Association of Physicians of India·2026

See all related articles

Interleukin-2 (IL-2), a cytokine, stimulates immune cells and is used therapeutically for HIV/AIDS, melanoma, and renal cell carcinoma. While effective, its main side effect is capillary leak syndrome.

Area of Science:

Immunology
Molecular Biology
Biochemistry

Background:

Interleukin-2 (IL-2) is a regulatory cytokine produced by T(H) lymphocytes and other cells.
It stimulates T lymphocyte proliferation and cytotoxicity, and enhances immune cell activities.

Purpose of the Study:

To review the therapeutic applications and adverse effects of Interleukin-2 (IL-2).
To highlight the role of IL-2 in managing various diseases.

Main Methods:

Recombinant DNA technology for large-scale IL-2 production.
Clinical studies evaluating IL-2 in HIV/AIDS, cancer, and autoimmune diseases.

Main Results:

IL-2 demonstrates therapeutic value in HIV/AIDS, metastatic melanoma, and renal cell carcinoma.

Related Experiment Videos

Soluble IL-2 receptor shows potential as a diagnostic marker for autoimmune diseases.

IL-2 antagonism is used for immunosuppression.

Conclusions:

IL-2 is a versatile therapeutic agent for immune modulation.
Capillary leak syndrome is the primary adverse effect.
IL-2 is expected to be crucial in managing viral infections and malignancies.