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Ageing and cell-mediated immunity.

B Fixa, O Komárková, V Chmelar

    Gerontologia
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Cell-mediated immunity, measured by lymphocyte transformation tests, declines significantly with age. Older adults showed a notable decrease in immune responsiveness, with many exhibiting pathologically low values.

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    Area of Science:

    • Immunology
    • Gerontology
    • Cell Biology

    Background:

    • Cell-mediated immunity is crucial for immune responses.
    • Assessing immune function across different age groups is important for understanding age-related health changes.

    Purpose of the Study:

    • To evaluate cell-mediated immune reactivity in healthy individuals across different age groups.
    • To determine the impact of aging on lymphocyte transformation response.

    Main Methods:

    • Utilized the lymphocyte transformation test (LTT) with phytohemagglutinin (PHA) as a mitogen.
    • Quantified cell-mediated reactivity by measuring 2-(14)C-thymidine incorporation into DNA.
    • Studied three age cohorts: up to 20 years, 21-40 years, and over 70 years, comprising 53 healthy subjects.

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    Main Results:

    • Lymphocyte responsiveness significantly decreased with advancing age.
    • The oldest age group (over 70 years) exhibited the most pronounced decline in immune function.
    • Twelve subjects in the oldest cohort presented pathologically low lymphocyte transformation values, indicating impaired cell-mediated immunity.

    Conclusions:

    • Aging is associated with a significant reduction in cell-mediated immune responsiveness.
    • The findings highlight potential age-related immune deficiencies in healthy elderly populations.
    • Further research is warranted to explore the clinical implications of these age-related immune changes.