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Published on: May 2, 2013
Successful pregnancy outcome in a lung transplant recipient with tacrolimus immunosuppression. A case report
Stephen J Kruszka1, Robert B Gherman
1Division of Maternal/Fetal Medicine, Department of Obstetrics and Gynecology, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708, USA.
Background:
The use of tacrolimus (FK506, PROGRAF) in pregnant lung transplant recipients has been very rarely reported.
Case:
A 32-year-old woman, gravida 1, para 0, had previously undergone a unilateral lung transplant secondary to pulmonary fibrosis. Four years later she spontaneously conceived. During pregnancy, she was maintained on an immunosuppressive regimen of tacrolimus and prednisone. Bi-weekly pulmonary function testing remained unchanged until 34 weeks' gestation. At that time, labor was induced due to concern for allograft rejection. A healthy, 2,208-g, female infant was born via an uncomplicated vaginal delivery. Postpartum transbronchial biopsy showed minimal acute cellular rejection.
Conclusion:
Lung transplant recipients may achieve successful pregnancy outcomes with the use of tacrolimus.
