Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Insulin therapy: optimizing control in type 1 and type 2 diabetes.

J Rosenstock1

  • 1University of Texas Southwestern Medical Center at Dallas, Dallas Diabetes and Endocrine Center, Dallas, Texas, USA.

Clinical Cornerstone
|February 13, 2002
PubMed
Summary

Insulin therapy is crucial for managing diabetes by lowering plasma glucose and preventing complications. Effective insulin replacement strategies mimic natural insulin secretion patterns to achieve near-normal glycemic control.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical perspectives from the BEGIN and EDITION programmes: Trial-level meta-analyses outcomes with either degludec or glargine 300U/mL vs glargine 100U/mL in T2DM.

Diabetes & metabolism·2018
Same author

Efficacy and safety of linagliptin as add-on therapy to basal insulin and metformin in people with Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2015
Same author

Efficacy and safety of liraglutide versus placebo added to basal insulin analogues (with or without metformin) in patients with type 2 diabetes: a randomized, placebo-controlled trial.

Diabetes, obesity & metabolism·2015
Same author

Impact of empagliflozin added on to basal insulin in type 2 diabetes inadequately controlled on basal insulin: a 78-week randomized, double-blind, placebo-controlled trial.

Diabetes, obesity & metabolism·2015
Same author

Efficacy and safety of LY2963016 insulin glargine compared with insulin glargine (Lantus®) in patients with type 1 diabetes in a randomized controlled trial: the ELEMENT 1 study.

Diabetes, obesity & metabolism·2015
Same author

Similar efficacy and safety of LY2963016 insulin glargine and insulin glargine (Lantus®) in patients with type 2 diabetes who were insulin-naïve or previously treated with insulin glargine: a randomized, double-blind controlled trial (the ELEMENT 2 study).

Diabetes, obesity & metabolism·2015

Area of Science:

  • Endocrinology
  • Pharmacology
  • Metabolic Diseases

Background:

  • Insulin has been a cornerstone of diabetes treatment for over 75 years.
  • It is essential for type 1 diabetes and widely used in type 2 diabetes management.
  • Near-normoglycemia is the primary goal to prevent long-term diabetes complications.

Purpose of the Study:

  • To review the physiologic basis of insulin secretion.
  • To discuss current therapeutic insulin agents.
  • To provide clinical guidelines for optimal insulin replacement strategies.

Main Methods:

  • Review of existing literature on insulin physiology and therapy.
  • Analysis of insulin replacement strategies simulating physiologic patterns.
  • Synthesis of practical clinical guidelines for glycemic control.

Related Experiment Videos

Main Results:

  • Insulin effectively lowers plasma glucose and can restore near-normoglycemia.
  • Physiologic insulin replacement strategies are key to achieving glycemic targets.
  • Optimal strategies address both basal and bolus insulin needs.

Conclusions:

  • Insulin remains a potent and versatile tool for diabetes management.
  • Simulating natural insulin secretion patterns is vital for effective glycemic control.
  • Clinical guidelines can help optimize insulin therapy for patients with type 1 and type 2 diabetes.